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A dry, annoying cough is a well-documented adverse effect of angiotensin converting enzyme (ACE) inhibitors. This class of medications works by inhibiting the enzyme responsible for converting angiotensin I to angiotensin II, which helps to lower blood pressure. One of the byproducts of this inhibition can lead to increased levels of bradykinin, a peptide that can stimulate cough reflexes in some individuals. Consequently, patients taking ACE inhibitors often report a persistent dry cough that can be bothersome.

The occurrence of this symptom is significant enough that it can lead healthcare providers to reconsider the use of an ACE inhibitor in favor of alternative antihypertensive agents if the cough is disruptive to the patient's quality of life. Monitoring for this specific symptom is an important part of patient care when initiating treatment with ACE inhibitors, as it can greatly influence adherence to the medication regimen.